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On the origin of mitosis-derived human embryo aneuploidy

Year: 2024
Type: article
Abstract: Chromosome segregation errors are common in the early stages of human embryonic development. By examining the first mitotic divisions of human embryos using live cell imaging, three recent studies identify spindle architecture and positioning features that could provide insights into why early embryos are predisposed to chromosomal abnormalities.
DOI: 10.1038/s41467-024-54953-0
Institution: Yale University
Language: English
Subfield: Cell Biology
Open Access status: gold
Estimated APC paid: $6,790
Funders: U.S. Department of Health and Human Services, Wellcome Trust, National Research Foundation, National Research Foundation of Korea, National Institutes of Health, National Institute of General Medical Sciences
Awards: G253727416, G414942675, G4919637430, G8485251301, G9000038284, Actin-based mechanisms of chromosome segregation in mammalian oocytes and embryos
OpenAlex ID: W4404855885
FWCI: 1.511
Cites: 27
Cited by: 8
Related to: 10