Molecular biomarkers for predicting complete response to preoperative chemoradiation in people with locally advanced rectal cancer
Year: 2024
Type: article
Study design: Study Protocol
Abstract: OBJECTIVES: This is a protocol for a Cochrane Review (prognosis). The objectives are as follows: Primary objectives To identify and estimate the prognostic value of molecular biomarkers as predictors of pathological complete response to neoadjuvant chemoradiotherapy in people with locally advanced rectal cancer. summarises the review question in population, index prognostic factor, comparator prognostic factor(s), outcome, timing, and setting (PICOTS) format. [Table: see text] [Figure: see text] Secondary objectives To explore the following biomarker measurement, treatment, and study design factors as possible sources of heterogeneity in the association between the prognostic factor and pathological response: type of assay/measurement method, biomarker positivity criteria or cut-off point, chemotherapy regimen, and radiotherapy regimen.
Authors: Penelope A De Lacavalerie, Sarah J Lord, Matthew J Morgan, Catherine E Caldon, Maija RJ Kohonen-Corish
Institutions: Garvan Institute of Medical Research, UNSW Sydney, Prince of Wales Hospital, Northern Sydney Local Health District, The University of Sydney, National Health and Medical Research Council, The University of Notre Dame Australia, Woolcock Institute of Medical Research, Western Sydney University, Macquarie University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4404859008