Effects of Motherwort on Biological Behavior of Brain Tissue in Rats with Ischemic Stroke and its Relationship with Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathway
Year: 2024
Type: article
Abstract: Background Motherwort has a protective effect on the nervous system and can improve cerebral ischemia–reperfusion injury to a certain extent. However, the effect of motherwort on the biological behavior of the brain tissue of rats with ischemic stroke and its relationship with the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway is still unclear. Objectives Therefore, we will explore the effect of motherwort on the biological behavior of the brain tissue of rats with ischemic stroke and its relationship with the PI3K/AKT signaling pathway. Materials and Methods There were 17 model rats in each group, divided into a control group, a model group, and a motherwort (low, medium, and high) dose group. Detect cell proliferation, invasion, and so on, and observe the expression of proteins and genes such as nuclear factor kappa B (NF-κB), AKT, Pl3K, and β-actin. Results After successfully constructing a rat model of ischemic stroke, motherwort can improve neurological damage and cerebral infarction in ischemic stroke and is closely related to PI3K/AKT signaling; in addition, motherwort can upregulate PI3K/AKT signaling and improve neurological damage and cerebral infarct size in ischemic stroke rats to a certain extent, and play a role in protecting neurons. Conclusion The antioxidant and antineuronal apoptosis effects of motherwort can improve neurological damage and cerebral infarction area of ischemic stroke rats by upregulating the expression level of the PI3K/AKT signaling pathway, thereby inhibiting nerve cells. Apoptosis further protects neurons and plays a role in slowing down disease progression.
Source: Pharmacognosy Magazine
Authors: Guangyu Cao, Jianju Zhou, Guoqing Yu, Xiaohong Fu, Bo Xiong
Institution: First People’s Hospital of Zunyi
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $1,600
OpenAlex ID: W4404861568