PET/CT Radiomics Integrated with Clinical Indexes as a Tool to Predict Ki67 in Breast Cancer: a Pilot Study
Year: 2024
Type: article
Study design: Observational Study
Abstract: Objective This study aims to assess the value of radiomics features integrated with clinical characteristics for estimating Ki67 expression in patients with breast cancer (BC). Methods In total, 114 patients with BC performed 18F-FDG PET/CT scans. Patients were randomly assigned to a training set (n = 79, 55 cases of Ki67 + and 24 cases of Ki67-) and a validation set (n = 35, 24 cases of Ki67 + and 11 cases of Ki67-). Thirteen clinical characteristics and 704 radiomics features were extracted, and 4 clinical and 8 radiomics features were selected. Three models were developed, including the clinical model, the radiomics model, and the combined model. Model performance was evaluated using the ROC curve, and clinical utility was assessed through decision curve analysis (DCA). Results The N stage, tumor morphology, SUVmax, and the longest diameter significantly differed between Ki67 + and Ki67- groups (all P < 0.05). Eight radiomics features were selected for the radiomics model. The area under the curve of the combined model in the training and test group was 0.90 (95% CI: 0.82∼0.97) and 0.81 (95% CI: 0.64∼0.99), respectively. The combined model significantly outperformed both the radiomics model and the clinical model alone (P < 0.05). The DCA curve demonstrated the superior clinical utility of the combined model compared to the clinical model and radiomics model. Conclusions PET/CT image-based radiomics features combined with clinical features have the potential to predict Ki67 expression in BC.
Authors: Dawei Li, Hui Ding, Yuting Liao, Xiao Yu, Youmin Guo, Cong Shen
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,790
Funder: Yakult Bio-Science Foundation
OpenAlex ID: W4404862483