Work

Palladium-Catalyzed Oxidative Cyclization of O -Aryl Cyclic Vinylogous Esters: Synthesis of Benzofuran-Fused Cyclohexenones

Year: 2024

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide This study presents a method for synthesizing functionalized hydrodibenzofuran derivatives. Using palladium catalysis, O -aryl cyclic vinylogous esters undergo dehydrogenative intramolecular arylation at the vinylic carbon. Preliminary kinetic isotope effect studies suggest that the C(aryl)–H bond cleavage may be the rate-determining step.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.4c02167

Authors: Ko-Wang Yen, Chia-Chen Chein, Shih-Hsun Wung, Li-Ching Shen, Yen-Ku Wu

Institution: National Yang Ming Chiao Tung University

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funder: National Science and Technology Council