Intravenous iron treatment fuels chronic kidney disease‐induced arterial media calcification in rats
Year: 2024
Type: article
Abstract: Arterial media calcification is a severe cardiovascular complication commonly manifesting in patients with chronic kidney disease (CKD). Patients with CKD frequently undergo intravenous iron therapy to address iron deficiency. Iron is suggested to be sequestered in vascular cells, potentially leading to oxidative (lipid) stress and cell death, which are recognized as key contributors to arterial calcification. The objective of this study was to investigate the effect of intravenous iron administration on CKD-induced arterial media calcification. Therefore, adenine-induced CKD rats were treated intravenously with iron and checked for arterial iron deposition and calcification, as well as for ferritin and lipid peroxidation markers. Additionally, arterial sections from patients with CKD who were dialysis dependent were analyzed for these parameters. This study showed that intravenous iron administration in CKD rats led to arterial iron deposition and a lipid peroxidation signature. CKD-induced arterial calcification was increased upon iron treatment and correlated with arterial iron accumulation and lipid peroxidation markers. Patients with CKD who were dialysis dependent showed arterial iron accumulation and elevated lipid peroxidation, but a direct correlation with arterial calcification was lacking. Taken together, iron treatment is suggested as a potential contributor to the calcification process, instead of being a predominant factor, thereby emphasizing the complexity of arterial calcification as a multifactorial disease. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Source: The Journal of Pathology
DOI: 10.1002/path.6375
Institutions: University of Antwerp, KU Leuven
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,190
Awards: Lipid peroxidation as a target to find innovative therapy for arterial media calcification: pre-clinical evaluation of novel membranous radical trapping molecules to halt this lethal disorder, Nanoparticle-based targeted delivery of therapeutics against arterial media calcification, a major cardiovascular complication in elderly and patients with chronic kidney disease, diabetes and osteoporosis., Targeting the endothelium to treat arterial media calcification: investigation of endothelial cell contribution to arterial media calcification and preclinical evaluation of restoring NO bioavailability to halt this lethal disorder, In depth investigation of causal pathophysiological mechanisms and underlying molecular signaling pathways of arterial stiffness, a life threatening disease with serious impact on multiple organs., Research network for Arterial Calcification
OpenAlex ID: W4404863700