Work

Evolutionary conservation analysis of human sphingomyelin metabolism pathway genes

Year: 2024

Type: article

Abstract: Sphingomyelin is an important member of the sphingolipid family and was first reported more than a century ago. It has been demonstrated that sphingomyelin plays a crucial role in compositing cell membranes and signaling pathways. Despite extensive functional studies on the sphingolipid metabolism pathway genes, one intriguing question remains: how does the emergence of these genes during evolution correlate with the acquisition of new functions in different species? By employing an evolutionary conservation analysis, the sequence of occurrence of biological processes during evolutionary history can be elucidated. Here we summarize and analyze the conservation status of the genes involved in sphingomyelin metabolism.

Source: Heliyon

DOI: 10.1016/j.heliyon.2024.e40810

Authors: Siyuan Wang, Huan Jiang, Moran Hu, Yingyun Gong, Hongwen Zhou

Institutions: Jiangsu Province Hospital, Nanjing Medical University

Language: English

Topic: Sphingolipid Metabolism and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,100

Funders: National Natural Science Foundation of China, China Postdoctoral Science Foundation, Priority Academic Program Development of Jiangsu Higher Education Institutions