Work

Research progress on the anti-tumor effects of protopanoxadiol

Year: 2024

Type: article

Abstract: Malignant tumors pose a significant threat to human life and health due to their high morbidity and mortality rates. Protopanoxadiol (PPD), a widely studied anti-tumor drug, has demonstrated promising anti-tumor effects in gynecological tumors, abdominal organs, and other malignancies. This review summarizes the anti-tumor mechanism of PPD in various types of cancers over the past 15 years, including its ability to inhibit tumor cell proliferation and migration, promote apoptosis, and suppress angiogenesis. Additionally, PPD’s mechanism involves regulating immune function and influencing the tumor microenvironment. By examining the anti-tumor effects of PPD in gynecological tumors, abdominal organs, and other malignancies, we aim to provide insights and methods for anti-tumor drug research, as well as offer a new direction and target for tumor treatment using traditional Chinese medicine.

Source: Inorganic Chemistry Communications

DOI: 10.1016/j.inoche.2024.113614

Authors: Ren Kaili, Luo Fei, Yang Rui

Institutions: Shanxi University of Medicine, Shanxi Medical University, Chinese Academy of Medical Sciences & Peking Union Medical College, Shanxi Provincial Cancer Hospital

Language: English

Topic: Phytochemical Studies and Bioactivities

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,450