The Role of Leukocyte Immunoglobulin Receptor B2 Overexpression as a Novel Biomarker and Potential Therapeutic Agent for Colorectal Cancer
Year: 2024
Type: article
Abstract: the researchers used gene platforms for online analysis of differentially expressed genes and mRNAs between normal and cancer tissues, which added to the protein-level experiments.Using tissue from the CRC and tissues adjacent to the CRC, the researchers compared the levels of expression of the LILRB2 protein [5].Additionally, they examined the correlation between LILRB2 mRNA expression and angiopoietinlike protein 2 (ANGPTL2) mRNA expression in CRC tissues, as well as the correlation between LILRB2 protein expression and ANGPTL2 protein expression.A comparison was also made between LILRB2 and traditional tumor markers using serum samples.Congratulations on the compelling findings of the research team [6].LILRB2 and its ligand ANGPTL2 were examined in detail for their role in the occurrence and development of CRC.In terms of this article, there are a few questions that require further consideration.Between 2021 and 2023,in a study the researchers collected 324 serum samples.CRC patients provided 132 preoperative serum samples, 91 postoperative serum samples, 87 adenoma patients provided 87 serum samples, and 14 healthy controls provided 14 serum samples.Following this, the researchers compared serum LILRB2 concentrations among patients with CRC, patients with adenoma, and healthy controls.They found statistically significant differences in LILRB2 concentrations between these three groups.Although the number of serum samples from CRC patients (197 samples) and health controls (15 samples) differ significantly, we would like to draw your attention to this disparity.The results of this research may be biased due to potential data bias [7].Furthermore, patients with normal colonoscopy may be included in the health control group
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4404866130