Work

Interactions of warfarin with COVID-19 vaccine/drugs, monoclonal antibodies, and targeted anticancer agents from real-world data mining

Year: 2024

Type: article

Abstract: Objective This study aims to examine the unresolved drug-drug interactions of warfarin using real-world data. Methods Electronic medical records from a hospital in Shanghai, China, were used to summarize drug-related problems (DRPs) among inpatients taking warfarin in 2022. Additionally, adverse event data for warfarin from January 2004 to December 2023 were extracted from the U.S. adverse event reporting system to evaluate the bleeding risk associated with the concomitant use of warfarin and COVID-19 Vaccine/drugs, monoclonal antibodies, and targeted anticancer agents. Results The electronic clinical records yielded 180 cases, of which 130 cases (72.22%) had 276 DRPs identified. DRP5 (n = 172, 62.32%) was identified as the most common issue, comprising 145 drug interactions and 27 adverse drug reactions (ADRs). The analyses of warfarin ADR records (n = 53,709) from the database revealed that tocilizumab (adjusted Odds Ratio (aOR): 3.39 [95% CI: 1.77–7.03]; P < 0.001), ibrutinib (aOR: 2.53 [1.61–4.19]; P < 0.001), and cabozantinib (aOR: 3.34 [1.40–9.85]; P = 0.013) significantly increased the risk of warfarin bleeding. In contrast, nirmatrelvir–ritonavir (aOR: 0.32 [0.14–0.69]; P = 0.004), adalimumab (aOR: 0.72 [0.56–0.93]; P = 0.012), golimumab (aOR: 0.18 [0.05–0.50]; P = 0.002), tofacitinib (aOR: 0.51 [0.29–0.86]; P = 0.013), and dabrafenib (aOR: 0.17 [0.04–0.55]; P = 0.007) significantly reduced the risk of bleeding when combined with warfarin. Remdesivir combined with warfarin was associated with a statistically significant increase in bleeding events (P = 0.047); while the risk was not significant after adjusting for age and sex (aOR: 1.79; P = 0.2). No significant effect was observed with the COVID-19 vaccine (aOR: 0.89; P = 0.8). Conclusion Drug-drug interactions contribute to the adverse effects of warfarin. This study provides real-world evidence of newly identified drug interactions with warfarin. It reminds clinicians to monitor INR and adjust warfarin doses accordingly when used in combination with these medications.

Source: Frontiers in Pharmacology

DOI: 10.3389/fphar.2024.1418997

Authors: Yan Gao, Qingsong Huang, Jun Li, Junsheng He, Fang Qian, Juanjuan Yi

Institutions: Shanghai Traditional Chinese Medicine Hospital, City University of Hong Kong

Language: English

Topic: Pharmacovigilance and Adverse Drug Reactions

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,295