Atypical Motor-Predominant Presentation of Subacute Combined Degeneration of Spinal Cord Due to Vitamin B12 Deficiency: A Case Report of Stroke Mimicry in the Absence of Classic Symptoms
Year: 2024
Type: article
Study design: Case Report
Abstract: Vitamin B12 deficiency is a prevalent condition that can lead to serious neurological disorders, including subacute combined degeneration (SCD) of the spinal cord, which can result in lasting damage if not promptly treated. This report discusses a unique case of a 53-year-old female patient who presented with a one-week history of gait instability and falls, ultimately diagnosed with SCD due to severe vitamin B12 deficiency. Notably, the patient exhibited an atypical presentation, lacking classic symptoms such as paraesthesia and hematologic abnormalities, which often accompany B12 deficiency. Clinical evaluation revealed no previous neurological deficits or hematological issues, suggesting an acute decline in B12 levels. Neuroimaging, particularly MRI of the spine, showed demyelination affecting the dorsal columns and corticospinal tracts, consistent with SCD while excluding ischemic causes. Laboratory tests confirmed low serum B12 levels, supporting the diagnosis. This case underscores the necessity for clinicians to maintain a high index of suspicion for vitamin B12 deficiency in patients presenting with unexplained neurological symptoms. Early intervention is crucial; in this case, immediate treatment with intramuscular B12 led to significant recovery in gait stability and neurological function. The findings highlight the importance of thorough assessments and ongoing education about the diverse presentations of B12 deficiency, especially in populations at risk, such as the elderly and those with malabsorption issues. Awareness of the neurological consequences of B12 deficiency is essential for effective management and improved patient outcomes.
Source: Cureus
DOI: 10.7759/cureus.74697
Authors: Zara Saeed, Syeda Ariba Zehra, Anwar Muhammad, Imran Ashraf
Institution: Dartford And Gravesham NHS Trust
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4404869573