Work

Acquired factor V inhibitor in a case of pediatric venous thrombosis

Year: 2024

Type: article

Abstract: Background: The development of acquired factor (F)V with inhibitor (AFVwI) is rare, resulting mainly in bleeding complications, although sporadic cases of thrombosis in adults have been reported. Key Clinical Question: How do you diagnose and manage a pediatric case of acute deep venous thrombosis associated with the concurrent finding of AFVwI? Clinical Approach: A 13-year-old female with Crohn's Disease and May-Thurner anatomy developed extensive deep venous thrombosis of the left lower extremity, complicated by the finding of AFVwI, discovered during the evaluation of a prolonged prothrombin time and a low FV activity. Anticoagulation was initiated with low-molecular-weight heparin followed by a direct oral anticoagulant, rivaroxaban, without any complications. AFVwI was undetectable after 5 months with normalization of FV activity. Conclusion: Our case highlights the first pediatric case of thrombosis with a rare finding of AFVwI, successfully managed with anticoagulation therapy with complete resolution.

Source: Research and Practice in Thrombosis and Haemostasis

DOI: 10.1016/j.rpth.2024.102646

Authors: Sweta Gupta, Matthew W. Bunce, Emily A. Cid, Rodney M. Camire, Amy D. Shapiro

Institutions: Indiana Hemophilia and Thrombosis Center, Children's Hospital of Philadelphia, University of Pennsylvania

Language: English

Topic: Blood Coagulation and Thrombosis Mechanisms

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,250