Correlation of Pre-transplant Meld Score With 30 and 60 Days' Mortality in Patients of Liver Transplant
Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The Model for End-Stage Liver Disease (MELD) score, introduced in 2002 by the United Network for Organ Sharing (UNOS), is a vital tool for predicting mortality for liver transplant candidates. Comprising serum creatinine, serum bilirubin, and international normalized ratio (INR), the MELD score includes kidney, liver, and coagulation pathway function, providing a comprehensive prognostic tool. Recent studies suggest broader prognostic implications, extending beyond organ allocation. Despite its benefits, around 15-20% of patients may not experience accurate survival predictions. METHODS: This retrospective single-center study, covering January 2016 to September 2023 with 87 patients, explores the correlation between pre-transplant MELD scores and 30 to 60-day post-transplant survival. RESULTS: Our analysis reveals no significant impact of MELD scores on survival during this period, challenging existing literature (p=0.068). The study underscores the need for nuanced risk assessment beyond MELD scores, considering diverse clinical scenarios and patient-specific variables. CONCLUSIONS: Our findings contribute to refining predictive models and advocate for larger-scale investigations, emphasizing a holistic approach to optimize liver transplantation outcomes.
Authors: Faryal Riaz Khan Khan, Rao Saad Ali Khan, Khawar Shabbir, Asim Shehzad, Fuad Ahmad Siddiqi, Zara Riaz Khan, Salahuddin, Muhammad Bilal Khattak
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4404883596