The evaluation of the mechanism of interleukin-6 in immune inactivation of oral cancer
Year: 2024
Type: article
Abstract: This study demonstrates the potential of sulindac to enhance resistance to tumor proliferation by both blocking tumor-induced immune suppression and stopping the growth of oral tumors. In contrast to adriamycin, sulindac significantly reduces the release of vascular endothelial growth factor (VEGF) and IL-6 from tumor cells by downregulating the NFκB and JNK signaling pathways. Additionally, it reduces the simultaneously induced production of VEGF and IL-6 during contacts between immune cells and tumors. Furthermore, sulindac dramatically reduces VEGF levels in the presence of IL-2-stimulated NK cells, indicating an improved immune response against tumor cells. Even the immunological suppression caused by tumor cells stimulated with TNF-α is reversed by sulindac. Consequently, the combination of sulindac with chemotherapy can effectively inhibit tumor growth and increase resistance to oral malignancies.
Authors: Suzan Mohammed Abdul Raheem, Esra Hassan Abd Ali, Al-zahraa J. Jassim, Nagham Falah Hasan, Abdullah J. Jasem
Institutions: Mustansiriyah University, Al-Esraa University, University of Wasit
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4404886411