Work

Exploring the Impact of Dietary Factors on Intestinal Diverticular Disease: A Mendelian Randomization Approach

Year: 2024

Type: article

Abstract: ABSTRACT Dietary habits significantly influence the development of intestinal diverticular disease (IDD), a common gastrointestinal condition primarily affecting the colon. We performed a Mendelian randomization (MR) analysis on 20 diet‐related factors using data from the UK Biobank. IDD cases ( n = 33,618) and controls ( n = 329,381) were obtained from the FinnGen Biobank. Three key MR methods were applied: the inverse‐variance‐weighted (IVW) method as the primary approach to estimate causal relationships, along with the weighted median (WM) and MR‐Egger methods. Significant associations were found for pork intake ( β = 1.06, p = 0.00244), nonoily fish intake ( β = 0.709, p = 0.0449), oily fish intake ( β = 0.246, p = 0.0222), and dried fruit intake ( β = −0.953, p < 0.0001). After false discovery rate (FDR) adjustment, pork intake ( q = 0.0244) and dried fruit intake ( q < 0.0001) remained significant. Our results indicate that while pork and certain types of fish intake may elevate the risk of IDD, dried fruit intake may offer a protective effect. These findings highlight the potential of dietary changes in IDD prevention and management, though further research across diverse populations is needed.

Source: Food Science & Nutrition

DOI: 10.1002/fsn3.4623

Authors: Wangzhao Tian, Wenwen Yang, Xiaorui Wang, Yanjiang Yang

Institutions: The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Lanzhou University, Chengdu University

Language: English

Topic: Diverticular Disease and Complications

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: hybrid

Estimated APC paid: $3,460