Work

Near-infrared-light mediated ZIF-8@Ti3C2Tx nanocomposite for synergistic antibacterial properties and biofilm ablation

Year: 2024

Type: article

Abstract: Due to the explosive emergence of various bacteria, antibiotics-free strategies are much needed for the elimination of bacterial-associated infections. Herein, ZIF-8@Ti3C2Tx nanocomposite was synthesized via in situ growth against bacteria under near-infrared-light (NIR) mediation. The integrated ZIF-8@Ti3C2Tx nanocrystal retained its NIR absorption, which enabled photothermal effect and reactive oxygen species (ROS) generation. Upon NIR irradiation, a sterilization rate of nearly 100% and a biofilm reduction rate of about 82% were obtained when the nanocomposite was treated with E. coli. It is suggested that the integration of ZIF-8@Ti3C2Tx facilitated the transfer of valence electrons to generate ROS, and the localized photothermal effect increased the release of Zn2+. Combined the photothermal therapy (PTT) with its evoked photodynamic therapy (PDT) and metal ions therapy (MIT), ZIF-8@Ti3C2Tx realized superior bactericidal activity and created a novel antibiotic-independent nanoplatform for biofilm ablation.

Source: Materials Research Express

DOI: 10.1088/2053-1591/ad99a6

Authors: Baoyong Xu, Zhipeng Hu, Wangzi Liu, Hong Li

Institution: Jinan University

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,880