Work

Evaluation of the Effects of Sedation and Anesthesia on Total Lung Volume and Attenuation in Rabbit Lung CT Exams

Year: 2024

Type: article

Abstract: Respiratory disease is common in rabbits, but subclinical conditions can be challenging to diagnose and may cause respiratory problems during anesthesia. CT is the preferred method for diagnosing lung diseases, but anesthesia can alter lung volume and cause lung lobe collapse. In this study, seventeen healthy 5-month-old male New Zealand white rabbits underwent thoracic CT scans under different conditions. Rabbits were sedated with midazolam and butorphanol and scanned in a sphinx position; they were then anesthetized with dexmedetomidine and ketamine and scanned again in sternal recumbency during spontaneous breathing. Lastly, apnea was induced using intermittent positive pressure ventilation (IPPV) for a final scan. Lung volume and density were measured using the 3D Slicer version 5.6.2 software, with thresholds set between −1050 and −100 Hounsfield Units (HU). Sedated animals had significantly higher total lung volume (69.39 ± 10.04 cm3) than anesthetized (47.10 ± 9.28 cm3) and anesthetized apnea rabbits (48.60 ± 7.40 cm3). Mean lung attenuation during sedation was −611.26 HU (right) and −636.00 HU (left). After anesthesia induction, values increased to −552.75 HU (right) and −561.90 HU (left). Following apnea induction, attenuation slightly decreased to −569.40 HU (right) and −579.94 HU (left). The results indicate that sedation may be preferable for rabbit lung CT to minimize anesthesia-related changes.

Source: Animals

DOI: 10.3390/ani14233473

Authors: Roberto Sargo, Inês Tomé, Filipe Silva, Mário Ginja

Institutions: University of Trás-os-Montes and Alto Douro, Centro de Ciência Animal e Veterinária

Language: English

Topic: Veterinary Pharmacology and Anesthesia

Subfield: Small Animals

Field: Veterinary

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,728