Work

Characterization of Persister Cells Provides Insights into Mechanisms of Therapy Resistance in Neuroblastoma

Year: 2024

Type: article

Abstract: The study by Grossmann and colleagues uses single-nucleus RNA sequencing in a cohort of matched high-risk neuroblastoma primary tumor samples, obtained from the same patient at diagnosis and definitive surgery, to identify persister cells that survive induction chemotherapy. These persister cells utilize mechanisms of chemoresistance that are both tumor-intrinsic and tumor-extrinsic, are highly dependent on the original genetic profile of the tumor, and represent novel, patient-specific targets to precisely inhibit chemoresistance and disease recurrence. See related article by Grossmann et.al., p. 2387.

Source: Cancer Discovery

DOI: 10.1158/2159-8290.cd-24-1357

Authors: Amber B. Wolf, C. Patrick Reynolds, Eveline Barbieri

Institutions: Baylor College of Medicine, Texas Tech University, Texas Tech University Health Sciences Center

Language: English

Topic: Neuroblastoma Research and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute