Maternal and Neonatal Outcomes Based on Changes in Glycosylated Hemoglobin Levels During First and Second Trimesters of Pregnancy in Women with Pregestational Diabetes: Multicenter, Retrospective Cohort Study in South Korea
Year: 2024
Type: article
Study design: Observational Study
Abstract: This study compared glycosylated hemoglobin (HbA1c) levels in the first and second trimesters of pregnancy and assessed maternal and neonatal outcomes according to HbA1c variations among women with pregestational diabetes. This retrospective, multicenter Korean study involved mothers with diabetes who had given birth in 17 hospitals. A total of 292 women were divided into three groups based on HbA1c levels during the first and second trimesters: women with HbA1c levels maintained at <6.5% (well-controlled [WC] group); women with HbA1c ≥ 6.5% (poorly-controlled [PC] group); and women with HbA1c ≥ 6.5% in the first trimester but <6.5% in the second trimester (improved-control [IC] group). The PC group had the highest pregnancy-associated hypertension (PAH) incidence, while the incidence did not significantly differ between the WC and IC groups. The receiver operating characteristic (ROC) curve indicated that HbA1c in the second trimester could predict PAH with a cut-off value of 5.7%. The PC versus WC versus IC group showed statistically significantly higher neonatal birthweight and significantly higher rates of large for gestational age (LGA); however, those were not significantly different between the WC and IC groups. HbA1c levels in the second trimester could predict LGA, with a cut-off value of 5.4%. Therefore, the second trimester HbA1c levels were significantly associated with both maternal and neonatal outcomes.
Source: Life
DOI: 10.3390/life14121575
Institutions: Kyungpook National University, Inha University, Inha University Hospital, The Catholic University of Korea Incheon St. Mary's Hospital, Catholic University of Korea, Sungkyunkwan University, Kyung Hee University, Kangwon National University, Yonsei University, Yonsei University Health System, Pusan National University, Seoul National University, University of Ulsan, Konkuk University, Keimyung University, St. Joseph Hospital, Korea University, The Catholic University of Korea Seoul St. Mary's Hospital
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,955
Funders: Dongguk University, Kangwon National University, Kyungpook National University, Pusan National University, University of Ulsan, Yonsei University, Kyung Hee University, Inha University, Konkuk University, Kyungpook National University Hospital, Pusan National University Hospital, Inha University Hospital, Samsung, Seoul St. Mary's Hospital, Catholic University of Korea
OpenAlex ID: W4404925114