Work

Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains

Year: 2024

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.4c01773

Authors: Oren L. Lederberg, Nicholas L. Yan, Julian Sanchez, Wen Ren, Carl Ash, Steven J. Wilkens, Huang Qiu, Bo Qin, Virginia H. Grant, Alex B. Jackman, Robyn L. Stanfield, Ian A. Wilson, H. Michael Petrassi, Derek Rhoades, Jeffery W. Kelly

Institution: Scripps Research Institute

Language: English

Topic: Amyloidosis: Diagnosis, Treatment, Outcomes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Center for Advancing Translational Sciences

Awards: G2027980179, High-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APS, G575095112, G606524477, G8265835771, G8984876448, Center for Biomolecular Structure (CBMS), Probing the Proteinopathy Component of Light Chain Amyloidosis Pharmacologically

OpenAlex ID: W4404945830

FWCI: 0.463

Cites: 41

Cited by: 4

Related to: 10