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Myxedema of the Larynx: An Underrecognized Cause of Airway Compromise in Patients With Severe Hypothyroidism

Year: 2024

Type: article

Abstract: Myxedema coma and severe hypothyroidism are rare diagnoses with a high rate of mortality. Associated respiratory failure is well recognized; however, airway compromise as the result of myxedema infrequently is discussed. We report a case of severe hypothyroidism resulting in respiratory compromise attributable to myxedematous infiltration of the larynx. A 62-year-old woman presented with confusion and severe hypothyroidism. Imaging demonstrated profound upper airway edema, and the results of a laryngoscopy suggested laryngeal myxedematous infiltration. She was emergently intubated and responded to thyroid hormone replacement. A review of the literature revealed 13 similar cases of laryngeal myxedema in patients with severe hypothyroidism, suggesting this complication may be more prevalent than initially appreciated.

Source: Annals of Internal Medicine Clinical Cases

DOI: 10.7326/aimcc.2024.0194

Authors: Kelsey Perry, Areeba Kara, Amy Munchhof

Institutions: Indiana University Indianapolis, Indiana University School of Medicine, Indiana University – Purdue University Indianapolis

Language: English

Topic: Thyroid Disorders and Treatments

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4404945930

FWCI:

Cites: 15

Cited by:

Related to: 10