Work

Oxygen-dependent alternative mRNA splicing and a cone-specific motor protein revealed by single-cell RNA sequencing in hypoxic retinas

Year: 2024

Type: article

Abstract: A RNA methylations in the hypoxic retina. Our data indicate that retinal cells adapt to hypoxic conditions by adjusting their transcriptome at various levels including gene expression, alternative splicing and the epitranscriptome. Adaptational processes may be cell-type specific as exemplified by the cone-specific upregulation of Kif4 or general like alternative splicing of RNA binding proteins.

Source: Experimental Eye Research

DOI: 10.1016/j.exer.2024.110190

Authors: Lynn J.A. Ebner, Duygu Karademir, Sarah Nötzli, Gabriele M. Wögenstein, Marijana Samardzija, Christian Grimm

Institutions: University of Zurich, University Hospital Zurich

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,860