Change in Systemic Medication and its Influence on Intraocular Pressure – Results From the Gutenberg Health Study
Year: 2024
Type: article
Study design: Observational Study
Abstract: Purpose: The purpose of this study was to investigate the relationship between the change in systemic medication and intraocular pressure (IOP) on a population-based level. Methods: The Gutenberg Health Study is a population-based prospective observational cohort study in Germany. As part of the baseline examination (2007-2012) and 5-year follow-up examination (2012-2017), IOP was measured by non-contact tonometry. Systemic medication was recorded at both time points. Multivariable regression analyses were carried out to analyze associations. Moreover, we calculated the dose-response relationship for the dosage change of selective beta-blockers with IOP change over 5 years. Results: The analysis population included 19,161 eyes of 9633 participants. IOP change was lower in participants with new intake of selective beta-blockers (-0.31 mm Hg, P < 0.001) and increased in those with discontinuation of selective beta-blocker intake (+0.28 mm Hg, P = 0.02). Associations between IOP change and statins and calcium channel blockers (CCBs) could be attributed to co-medications. There was a dose-response relationship for change in selective beta-blocker intake and change in IOP (-0.16 mm Hg/100 mg, P = 0.02). Conclusions: Use of systemic selective beta-blockers is associated with an IOP change on a population level, whereas the association with other systemic medications on IOP change could be explained by co-medication use or change in blood pressure. Patients undergoing IOP monitoring and management should routinely be asked about changes in systemic medications.
DOI: 10.1167/iovs.65.14.4
Authors: Panagiotis Laspas, Alica Hartmann, Ida Scholz, Esther Maria Hoffmann, Anthony P. Khawaja, Karl Johannes Lackner, Thomas Münzel, Jasmin Ghaemi Kerahrodi, Irene Schmidtmann, Oliver Tüscher, Jörn Markus Schattenberg, Norbert Pfeiffer, Stavros Konstantinides, Philipp Sebastian Wild, Alexander Karl-Georg Schuster
Institutions: University Medical Center of the Johannes Gutenberg University Mainz, Moorfields Eye Hospital NHS Foundation Trust, NIHR Moorfields Biomedical Research Centre, University College London, Johannes Gutenberg University Mainz, Leibniz Institute for Resilience Research, Institute of Molecular Biology, German Centre for Cardiovascular Research
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,850
Funders: Pfizer, Sanofi, Gilead Sciences, Deutsches Zentrum für Herz-Kreislaufforschung, Inventiva Pharma, Intercept Pharmaceuticals, Apellis Pharmaceuticals, National Institute for Health and Care Research, Lister Institute of Preventive Medicine, Bundesministerium für Bildung und Forschung, Novo Nordisk, Santen, Stiftung Rheinland-Pfalz für Innovation, Deutsche Ophthalmologische Gesellschaft, Heidelberg Engineering, Siemens Healthineers, Moorfields Eye Hospital NHS Foundation Trust, Ipsen, Allergan, Bayer Vital, Alcon Research Institute
OpenAlex ID: W4404963400