Work

Mechanochemical kilogram-scale synthesis of rac -ibuprofen:nicotinamide co-crystals using a drum mill

Year: 2024

Type: article

Abstract: An eco-friendly mechanochemical process for synthesizing rac -ibuprofen:nicotinamide co-crystals using a drum mill at kilogram scale is presented. This method yields 99% pure co-crystals in 90 min with minimal metal contamination.

Source: RSC Mechanochemistry

DOI: 10.1039/d4mr00096j

Authors: Jan-Hendrik Schöbel, Frederik Winkelmann, Joel Bicker, Michael Felderhoff

Institution: Max-Planck-Institut für Kohlenforschung

Language: English

Topic: Crystallography and molecular interactions

Subfield: Physical and Theoretical Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: diamond

Funders: BASF, European Commission, HORIZON EUROPE Framework Programme

Award: G4827025924

OpenAlex ID: W4404965296

FWCI: 1.863

Cites: 72

Cited by: 9

Related to: 10