Revisiting the diagnostics of immunopathological conditions
Year: 2024
Type: article
Abstract: The immune system is one of the main regulatory homeostatic systems in the human body. The immune homeostasis is maintained by numerous versatile mechanisms. Immune system dysfunction leads to various immunopathological conditions. One of the major challenges is identifying immune system diseases and clinical conditions associated with reversible immune system dysfunctions. In the first case, these conditions may be determined as persistent immune dysfunctions; in the second case, as transient ones. Immunopathological conditions are manifested by various immunological symptoms and signs (syndromes) disrupting normal bodily functions as a result of immune system impairment. Accordingly, clinical practice implies the need to detect a particular immunopathological syndrome, determine its characteristics, assess its severity, identify its causes, perform additional laboratory studies and clinical investigations, and establish a specifically immunological diagnosis. However, no general clinical criteria for diagnosing immunopathological conditions are presently available. A discussion is proposed to be held in order to identify and describe the clinical symptoms associated with dysfunctions of various immune system components. This will serve as a valuable reference for practicing physicians who conduct immunoactive therapy.
Source: Cytokines and inflammation
DOI: 10.17816/ci634730
Authors: Vladimir A. Kozlov, Andrey A. Savchenko, Andrey S. Simbirtsev, Irina V. Demko, Elena N. Anisimova, Alexander G. Borisov
Institutions: Krasnoyarsk Scientific Center, Research Institute of Medical Problems of the North, Research Institute of Fundamental and Clinical Immunology, Krasnoyarsk State Medical University, Siberian Branch of the Russian Academy of Sciences, State Research Institute of Highly Pure Biopreparations, Krasnoyarsk Regional Clinical Hospital
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4404975037