Supplementary Figure S7 from TR-107, an Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells
Year: 2024
Type: supplementary-materials
Abstract: Supplementary Figure S7. TR-107 reduces mitochondrial metabolic function in CRC cells. (A-D) Mitochondrial oxygen consumption rate (OCR) and (E-H) glycolytic proton efflux rate (PER) were evaluated in colorectal cancer cells LoVo, NCI-H508, LS 174T, and RKO treated with vehicle control (0.1% DMSO) or indicated concentrations of TR-107 for 12 hours. Quantification of OCR and PER was measured with the Seahorse XF Real-Time ATP Rate Assay. Baseline rates were captured for the first three time points, followed by injection of indicated compounds at concentrations described in Materials and Methods. Data are presented as mean ± SD values (N=6).
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4404976124