Supplementary Figure S10 from TR-107, an Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells
Year: 2024
Type: supplementary-materials
Abstract: Supplementary Figure S10. TR-107 downregulates the expression of essential mitochondrial proteins. Colorectal cancer cells (A) LoVo, (B) NCI-H508, (C) LS 174T, and (D) RKO were treated with vehicle control (0.1% DMSO) or TR-107 (50 nmol/L) for 24 hours. Immunoblot (N=3) was performed for various mitochondrial regulatory and metabolic proteins. (E-H) Band densitometry analysis was conducted to quantify relative protein expression and normalized to β-actin control. Densitometry was measured with ImageJ and analyzed with GraphPad Prism as described in Materials and Methods. Data are presented as mean ± SD values (N=3). *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4404976296