Year: 2024
Type: conference-paper
Abstract: As substances carrying genetic information, the properties of DNA molecules, such as natural programmability and the ability of information storage, provide a brand-new implementation method for constructing biocompatible logic circuits at the nanoscale. This paper proposes a cooperative hairpin DNA strand displacement mechanism, and based on this mechanism, two primitive DNA logic gates including OR gate and INHIBIT gate are constructed. In addition, an OR-INHIBIT DNA circuit are realized by juxtaposing these basic DNA logic gates in an isomorphic way. The transformation of the functions of basic logic gates and logic circuits is achieved by changing the auxiliary signal strands and input strands, which greatly reduces the complexity of DNA circuits. This construction method can enrich the toolbox for DNA circuit construction and contribute to the development of fields such as biosensors and biocomputing.
Authors: Xuedong Zheng, Zixin Qiu, Renjie Ma, Shilin Tan
Institution: Shenyang Aerospace University
Language: English
Topic: DNA and Biological Computing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Award: DNA核酶置换驱动的DNA计算模型研究
OpenAlex ID: W4404978163