Work

Understanding how the structures of surfactants in hybrid nanoparticles affect the compaction of ct-DNA for cellular uptake: presenting a highly efficient surfactant

Year: 2024

Type: article

Abstract: cellular uptake of the gene to 4T1 cells have been investigated. This study provides ideas for designing efficient non-viral vectors. Overall, DDAB18-coated silica nanoparticles appear to be safe and effective DNA compaction agents that can carry nucleic acids for biomedical applications.

Source: Soft Matter

DOI: 10.1039/d4sm01345j

Authors: Shalini Dyagala, Milan Paul, Vinod K Aswal, Swati Biswas, Subit Kumar Saha

Institutions: Birla Institute of Technology and Science - Hyderabad Campus, Birla Institute of Technology and Science, Pilani, Bhabha Atomic Research Centre

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Department of Science and Technology, Ministry of Science and Technology, India, Indian Council of Medical Research, Birla Institute of Technology and Science, Pilani, UGC-DAE Consortium for Scientific Research, University Grants Commission