Work

Optimization and Characterization of Self Nano Emulsifying Drug Delivery System (SNEDDS) of Curcumin with D-Optimal Mixture Design Method

Year: 2024

Type: article

Abstract: Curcumin, known for its anti-inflammatory, antibacterial, anticarcinogenic, and antioxidant properties, faces challenges due to poor water solubility and low bioavailability as a BCS class II compound. The study investigates using a self-nanoemulsifying drug delivery system (SNEDDS) to enhance these properties, optimizing the formulation with the D-Optimal Mixture Design method. Sixteen formulas were prepared using oleic acid, Tween 80, and PEG 400. Each formula was characterized by particle size, % transmittance, emulsification time, and drug loading. The optimized formula, containing 10% oleic acid, 70% Tween 80, and 20% PEG 400, achieved a particle size of 80.167 nm, an emulsification time of 39.36 seconds, near 100% transmittance, and high drug loading.

Source: East Asian Journal of Multidisciplinary Research

DOI: 10.55927/eajmr.v3i11.12051

Authors: Mulyaningtyas Ayu Kusumawati, Iswandi Iswandi, Ilham Kuncahyo

Institution: Universitas Setia Budi

Language: English

Topic: Drug Solubulity and Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4404984473

FWCI: 0.148

Cites:

Cited by: 1

Related to: 10