Work

Manganese Promoted Reductive Cross‐Coupling of Phosphine Chlorides with Disulfides for the Synthesis of Thiophosphanes

Year: 2024

Type: article

Abstract: Herein we reported a manganese promoted reductive cross‐coupling approach to construct P−S bond. This is a practical method for the synthesis of mono‐thiophosphanes, bis‐thiophosphanes and tri‐thiophosphanes under mild conditions. The strategy featured a wide range of substrate scope including various disulfides and phosphine chlorides, constructing diverse sulfur‐containing organophosphorus compounds from inodorous and readily available starting materials. The employment of reductive conditions avoided the generation of phosphorothioates (P V ) by‐products. Ultimately, gram‐scale synthesis and applications were explored. Extensive experiments indicated that the phosphine radical cascade process was involved in the catalytic cycle.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.202401395

Authors: Chao‐Peng Zhang, Tian‐Zhang Wang, Zhong‐Jiang Yang, Yu‐Feng Liang

Institution: Shandong University

Language: English

Topic: Organophosphorus compounds synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $4,430

Funder: National Natural Science Foundation of China