Year: 2024
Type: article
Abstract: Transition-metal-catalyzed C(sp3)-H bond functionalization is a useful transformation for the construction of C–C bonds. A versatile and easy-to-perform protocol in this respect is the C-alkylation of methyl heteroarenes with alcohols using auto-transfer hydrogenative (ATH) reactions. Various transition metal catalysts based on Ir, Pt, Ru, Ni, Co, Fe and Mn have been employed for the construction of chain-elongated alkyl-substituted heterocyclic compounds using this chemistry. Water is the only byproduct and the starting alcohols are less toxic, readily available, more easily handled and more atom-economical substrates than their halogen counterparts. This review details recent advances in this synthetic methodology, describing the scope, reaction mechanism, chemo-selectivity and applications.
Source: Catalysts
Authors: Bin Guo, Jing Zhang, Lin He, Xin-Yuan Zhou, Kai-Wen Xing, David J. Young, Hong-Xi Li
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,069
OpenAlex ID: W4404993722