Sub-acute stroke demonstrates altered beta oscillation and connectivity pattern in working memory
Year: 2024
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Working memory (WM) is suggested to play a pivotal role in relearning and neural restoration during stroke rehabilitation. Using EEG, this study investigated the oscillatory mechanisms of WM in subacute stroke. METHODS: This study included 48 first subacute stroke patients (26 good-recovery, 22 poor-recovery, based on prognosis after a 4-week period) and 24 matched health controls. We examined the oscillatory characteristics and functional connectivity of the 0-back WM paradigm and assessed their associations with prognosis. RESULTS: Patients of poor recovery are characterised by a loss of significant beta rebound, beta-band connectivity, as well as impaired working memory speed and performances. Meanwhile, patients with good recovery have preserved these capacities to some extent. Our data further identified beta rebound to be closely associated with working memory speed and performances. CONCLUSIONS: We provided novel findings that beta rebound and network connectivity as mechanistic evidence of impaired working memory in subacute stroke. These oscillatory features could potentially serve as a biomarker for brain stimulation technologies in stroke recovery.
Authors: Lin Mao, Xianwei Che, Juehan Wang, Xiaorui Jiang, Yifan Zhao, Liliang Zou, Shuang Wei, Shuyi Pan, Dazhi Guo, Xueqiong Zhu, Dongxia Hu, Xiaofeng Yang, Zuobing Chen, Daming Wang
Institutions: First Affiliated Hospital Zhejiang University, Zhejiang University, Hangzhou Normal University, Affiliated Hospital of Hangzhou Normal University, First People's Hospital of Yuhang District, Chinese PLA General Hospital, Nanchang University, Second Affiliated Hospital of Nanchang University
Language: English
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,690
Award: G2951896785
OpenAlex ID: W4404994374