Work

Gut microbiota and dynamics of ammonia metabolism in liver disease

Year: 2024

Type: article

Abstract: Blood ammonia levels in healthy individuals are low, but they increase in liver disease due to loss of functional liver mass and portosystemic shunting. Hyperammonemia is one of the key factors involved in the prognosis of cirrhosis and its complications. Here we review to establish a connection between alterations in gut microbial communities and intestinal ammonia metabolism, highlighting a key impact of gut dysbiosis on blood ammonia levels during liver disease.

Source: npj gut and liver.

DOI: 10.1038/s44355-024-00011-x

Authors: Deepika Jakhar, Shiv K. Sarin, Savneet Kaur

Institution: Institute of Liver and Biliary Sciences

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,790