Year: 2024
Type: article
Abstract: The aim of this study was to evaluate the antibacterial effects of Paeonia lactiflora (PL) extract on oral microcosm biofilms and determine its usefulness as a natural alternative to current antimicrobial agents. Oral biofilms were cultivated on hydroxyapatite disks using human saliva for 2 days, following which they were treated with 1.5 mL of distilled water (DW), 30 μg/mL of PL extract, or 0.12% chlorhexidine gluconate (CHX) once daily for 3 days. Antibacterial effects were assessed by measuring red fluorescence intensity (RatioR/G), bacterial viability (RatioG/G+R), and aciduric bacterial counts. RatioR/G was evaluated using quantitative light-induced fluorescence digital imaging. RatioR/G and RatioG/G+R in the PL group were 0.94-fold and 0.73-fold lower than those in the DW group (p < 0.001 and p = 0.011, respectively) and comparable to those in the CHX group (p = 0.356 and p = 0.964, respectively). Aciduric bacterial counts in the PL group were 0.97-fold lower than those in the DW group (p < 0.001), with no significant difference from those in the CHX group (p = 0.892). Thus, the antibacterial effect of PL extract was comparable to that of CHX; this suggests its potential as a natural alternative for managing oral biofilm-associated diseases.
Source: Applied Sciences
DOI: 10.3390/app142311290
Authors: Ji-Won Lim, Min-Kyung Kang, Hee-Eun Kim
Institutions: Gachon University, Hanseo University
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,728
Award: G2880693177
OpenAlex ID: W4405003460