Left Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement
Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND: In aortic stenosis, the myocardium responds with left ventricular hypertrophy, which is characterized by increased left ventricular mass due to cellular hypertrophy and extracellular matrix expansion. Following aortic valve replacement (AVR), left ventricular hypertrophy regression occurs, but early cellular and extracellular dynamics are unknown. METHODS: Patients with severe symptomatic aortic stenosis undergoing surgical or transcatheter AVR were prospectively recruited. Pre- and early post-AVR cardiac magnetic resonance imaging assessed left ventricular remodeling, global longitudinal strain, and T1 mapping to determine extracellular volume fraction and volume of cellular and extracellular compartments. RESULTS: values indicates a statistical significance of <0.05. CONCLUSIONS: Within 8 weeks of AVR for aortic stenosis, substantial left ventricular hypertrophy regression occurs involving both cellular and extracellular compartments, demonstrating the early myocardial adaptability to afterload relief. Cellular compartment regression is greater than extracellular regression, leading to an apparent increase in extracellular volume fraction. Mode of intervention did not affect degree of reverse remodeling, indicating that both are effective at resulting beneficial changes post-AVR. REGISTRATION: URL: https://www.isrctn.com; Unique identifier: NCT04627987.
Authors: Jonathan Bennett, George D. Thornton, Christian Nitsche, Francisco F. Gama, Nikoo Aziminia, Uzma Gul, Abhishek Shetye, Peter Kellman, Rhodri H. Davies, James C. Moon, Thomas A. Treibel, Benjamin Adams, Shirish Ambekar, Dincer Aktuerk, Wael Awad, Andreas Baumbach, Sanjeev Bhattacharyya, Carmelo Di Salvo, Shyamsunder Kolvekar, Kulvinder Lall, David Lawrence, Miss Ana Lopez-Marco, Guy Lloyd, Simon Kennon, Charlotte Manisty, Anthony Mathur, Rok Mravljak, Michael Mullen, Aung Oo, Mick Ozkor, Iain Pierce, Neil Roberts, Amir Sheikh, Alex Shipolini, Rakesh Uppal, Phooi Kit Wong, Martin Yates, John Yap
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4405004870