Temporal integration on the dendrites of fast-spiking basket cells
Year: 2024
Type: article
Abstract: Neurons receive synaptic inputs with diverse temporal patterns in vivo, and their integration of these patterns is critical for understanding information processing mechanisms in the brain. Fast-spiking basket cells, which perform both supralinear and sublinear dendritic integration, are essential for inhibitory control in the hippocampus. However, their responses and the mechanisms underlying different temporal input patterns remain unclear. To address this question, we apply inputs with varying windows of time to a detailed compartmental model of basket cells. Our results reveal that when synaptic inputs are randomly dispersed, temporal integration in FS BCs exhibits a sigmoid-like response within the temporal window. In contrast, synchronous input protocols more effectively elicit action potentials, while asynchronous inputs generate more spikes in response to suprathreshold stimuli. Further analysis shows that the supralinear dendrites of fast-spiking basket cells primarily mediate this nonlinearity to asynchronous inputs, owing to their larger dendritic diameters. Moreover, we discover that delayed rectifier [Formula: see text] channels reduce sensitivity to synchronous inputs, whereas N-type [Formula: see text] channels enhance sensitivity to asynchronous inputs. These results provide insights into the mechanisms underlying the temporal coding of fast-spiking basket cells, which is crucial for understanding their role in neuronal oscillations.
Source: Scientific Reports
Authors: Ming Liu, Xiaojuan Sun
Institution: Beijing University of Posts and Telecommunications
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,590
Award: G8743929115
OpenAlex ID: W4405009129