Work

Comparative Proteomic Analysis of Endolymphatic Sac Luminal Fluid in Patients with Meniere’s Disease and Controls

Year: 2024

Type: article

Abstract: Introduction: Meniere's disease (MD) is known to be caused by the dysfunction of the endolymphatic sac (ES), but its molecular mechanism is unknown. Methods: We performed a comparative proteomic analysis of ES luminal fluids (ELFs) from patients with MD and controls. Results: We found 6 differentially expressed proteins, including 2 significantly increased proteins and 4 significantly decreased proteins, 8 proteins identified exclusively in at least 7 of the 8 ELF samples from MD patients and 3 proteins detected solely in at least 4 of the 5 ELF samples from controls. Discussion: The increased levels of IGLV 3-9 and IGLV1-47 in MD group compared with control group suggested an increased inflammatory reactions and a decreased level of Aldehyde dehydrogenase 2 in MD group compared with control group might result in oxidative damage and inflammatory lesions in the ES of MD. Whereas CD44 identified exclusively in MD samples might be involved in the metabolism of its ligand, hyaluronic acid for overproduction of endolymph in the ES of MD.

Source: Journal of Inflammation Research

DOI: 10.2147/jir.s474910

Authors: Zhiwen Zhang, Qin Wang, Zhou Zhou, Anquan Peng, Wenqi Jiang

Institutions: Central South University, Second Xiangya Hospital of Central South University, Xiangya Hospital Central South University, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China

Language: English

Topic: Vestibular and auditory disorders

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836