Differences in splicing factors may predict type 2 diabetes remission in the CORDIOPREV study
Year: 2024
Type: article
Abstract: Alternative splicing is a post-transcriptional process resulting in multiple protein isoforms from a single gene. Abnormal splicing may lead to metabolic diseases, including type 2 diabetes mellitus (T2DM). To identify the splicing factor expression that predicts T2DM remission in coronary heart disease (CHD) patients, we identified newly diagnosed T2DM at baseline ( n = 190) from the CORDIOPREV study. Patients were classified as Responders (T2DM remission during 5 years without antidiabetic drugs) or non-Responders. Baseline dysregulation in 5 splicing factors ( MBNL1 , RBM5 , hnRNP G/RBMX , CD44 , NT5E ) distinguished Responders from non-Responders. Adding these factors to clinical variables [AUC = 0.67], insulin resistance, and beta-cell indexes [AUC = 0.76], improved T2DM remission prediction [AUC = 0.80]. Cox regression analysis showed those with higher remission scores had a 2.63-fold increased remission probability. To conclude, a set of splicing factors that contribute to predicting T2DM remission in patients with CHD has been identified. Further research is needed to elucidate these findings' clinical relevance.
Source: iScience
Authors: Ana Ojeda-Rodriguez, Jose D. Torres-Peña, Antonio Pablo Arenas-de Larriva, Oriol Alberto Rangel-Zuñiga, Alicia Podadera-Herreros, Hatim Boughanem, Miguel E. G-García, Alejandro López-Moreno, Niki Katsiki, Raul M. Luque, Pablo Perez-Martinez, Javier Delgado-Lista, Elena M. Yubero-Serrano, Jose Lopez-Miranda
Institutions: Instituto de Salud Carlos III, Instituto Maimónides de Investigación Biomédica de Córdoba, Centro de Investigación Biomédica en Red, Hospital Universitario Reina Sofía, University of Córdoba, International Hellenic University, European University Cyprus, Consejo Superior de Investigaciones Científicas, Instituto de la Grasa
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,150
Awards: G279363373, G3188400181, G3435408474, G3473816158, G589296787, G6312668090, Influencia de la obesidad en la evolución de la nefropatía diabética. Consumo de dos modelos de dieta cardiosaludables como estrategia terapéutica en el desarrollo de la enfermedad, G6594241516, Efecto del consumo de dos dietas saludables sobre el metabolismo de los productos finales de glicación avanzada y su influencia en el riesgo de arteriopatía periférica en pacientes con enfermedad coronaria, G8980970611
OpenAlex ID: W4405012060