Synthesis, structure identification, antioxidant and antimicrobial activities of some novel quinoline derivatives
Year: 2024
Type: article
Abstract: Excellent yields (moreover 87%) were achieved in the single-step synthesis of a number of new quinoline compounds, in an ethanolic medium containing various aromatic substituted benzaldehydes, N -phenylacetamide hydrate, and 5,5-dimethylcyclohexane-1,3-dione. The quinoline derivatives were confirmed by mass spectroscopy and Nuclear Magnetic Resonance Spectroscopy (NMR). Strains of pathogenic bacteria and fungi were employed to assess the antimicrobial properties. Aspergillus niger , Aspergillus flavus , Aspergillus fumigatus and Candida albicans were the fungal strains used in the study, whereas the bacterial strains were Enterobacter cloacae, Staphylococcus haemolyticus , Bacillus cereus , and Staphylococcus aureus . For the bacterial and fungal investigations, respectively, ciprofloxacin and fluconazole were utilized as references, with Dimethyl Sulfoxide (DMSO) serving as the control. Quinoline derivatives 1 , 2 , 3 , and 5 exhibit the highest level of antibacterial activity against all strains of bacteria, whereas quinoline derivatives 4 , 5 demonstrate the highest level of inhibitory activity against all strains of fungi. The complexes were subjected to a Nash method inspection using their ability to scavenge hydroxyl (OH·) radicals. Additionally, the superoxide radical was indirectly evaluated using the MET-VitB2-NBT system. Using common vitamin C drugs, the overall antioxidant activity of the quinoline derivatives ( 1 – 5 ) was evaluated in an effort to identify possible antioxidants and therapeutic agents for respiratory conditions such as asbestosis, emphysema, and asthma. The results revealed that the compounds 5 and 3 possess significant antioxidant activity. Quinoline derivatives are a promising possibility for further biomedical research and therapeutic development due to antioxidant characteristics and their synthesis and characterisation.
Source: Discover Chemistry.
Authors: Immani Ramachandra Rao, P. Punitha, B. Premalatha, Thota Siva Prasad, M. Suresh
Institutions: Annamalai University, Andhra University, Periyar University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4405012689