Work

A convenient synthesis of CHF2O-containing pyrrolidines and related compounds — Perspective building blocks for drug discovery

Year: 2024

Type: article

Abstract: Fluorine-containing organic molecules, including CHF2O-derivatives, are among the most sought-after in medicinal chemistry. In the current work, a mini-library of 21 compounds with a CHF2O-motif incorporated with azetidine, pyrrolidine (proline), piperidine, 2-azabicyclo[2.2.1]heptane, and 8-azabicyclo[3.2.1]octane cores were synthesized. A multigram scale (10 to 30 g) procedure for synthesizing title compounds from commercially available amino alcohols was studied.

Source: SynOpen

DOI: 10.1055/a-2407-4709

Authors: Kostiantyn Levchenko, Ivan Virstiuk, Daria Menshykova, Nazariy Pokhodylo

Institutions: Lviv University, Enamine (Ukraine), National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $340

OpenAlex ID: W4405013046