Work

Distribution of keratin subtypes in the thymus of Japanese black calves during acute thymic involution

Year: 2024

Type: article

Abstract: Immunohistochemistry for keratins 5, 8, 14, and 18 was performed on Japanese Black calf thymuses at various stages of acute thymic involution. Keratins 5 and 14 were predominantly localized in the thymic medulla, while keratins 8 and 18 were broadly distributed throughout the parenchyma. Despite thymic involution, the distribution patterns of these keratins remained consistent. The cortical area, assessed by keratin 5 staining, progressively decreased with involution but retained approximately 40% of the total parenchyma even at the most severe stage. These results suggest that the thymic cortex shrinks but does not completely disappear during acute thymic involution in calves.

Source: Journal of Veterinary Medical Science

DOI: 10.1292/jvms.24-0413

Authors: Shoichi WAKITANI, Risako KAWABATA, Sora SHIRATAKI, Masahiro YASUDA

Institution: University of Miyazaki

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: diamond

Funder: Japan Society for the Promotion of Science

Award: Characterization of cortical thymic epithelial cells in weak calf syndrome