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Effect of Common Medications on Longitudinal Pectoralis Muscle Area in Smokers

Year: 2024
Type: article
Abstract: Background: Cigarette smoke contributes to skeletal muscle wasting. While exercise and nutritional therapies are effective in improving skeletal muscle quantity and quality, the effect of medications on longitudinal muscle loss is unclear. We investigated whether long-term use of common medications affects longitudinal skeletal muscle changes in current and former smokers. Methods: ) study. We tested whether specific medications were associated with delta-PMA and/or delta-PMD using regression analyses. Propensity score matching (PSM) analysis was performed to determine the effect of the medications on longitudinal changes on delta-PMA. Results: =0.040). Conclusion: In current and former smokers, statin use was associated with reduced pectoralis muscle wasting, while aspirin use was associated with increased muscle loss. Additional research is needed to verify these findings. (Clinicaltrials.gov identifier NCT00608764).
DOI: 10.15326/jcopdf.2024.0557
Authors: Toru Shirahata, Nicholas A. Enzer, Victor Castro, Joe Chiles, Merry-Lynn McDonald, Bina Choi, Alejandro A. Diaz, George R. Washko, Raúl San José Estépar, Samuel Y. Ash, Farbod N. Rahaghi
Institutions: Brigham and Women's Hospital, Harvard University, Saitama Medical University, Boston University, University of Alabama at Birmingham, UAB Medicine, Tufts University, South Shore Hospital
Language: English
Subfield: Physiology
Field: Medicine
Open Access status: diamond
Funders: Pfizer, AstraZeneca, GlaxoSmithKline, COPD Foundation, Sunovion, National Institutes of Health, Genentech, National Heart, Lung, and Blood Institute
Awards: G2150151983, G2644038179, G377726100, G5258357286, (2 of 2) Genetic Epidemiology of COPD, G8354759825, G8643874822, G8819318481
OpenAlex ID: W4405016884
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