Work

A GAME changer in steroidal metabolite biosynthesis

Year: 2024

Type: article

Abstract: Continuous adaptation to changing environmental conditions is an evolutionary trait that many plant species have acquired to cope with biotic and abiotic stresses. Several plant families have adapted to synthesize a wide range of specialized metabolites, many of which serve protective functions. The significant biological activities of these specialized metabolites have been exploited by humans for pharmacological purposes. Notable examples include the monoterpenoid indole alkaloids vinblastine and vincristine from the Madagascar periwinkle (Apocynaceae) and the sesquiterpene lactone artemisinin from the annual wormwood (Asteraceae), which are used to treat cancers and malaria, respectively.

Source: Plant Communications

DOI: 10.1016/j.xplc.2024.101201

Authors: Enzo Lezin, Nicolas Papon, Vincent Courdavault

Institutions: Université de Tours, Biomolécules et Biotechnologies Végétales, Université d'Angers

Language: English

Topic: Plant biochemistry and biosynthesis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,750

Funders: European Commission, Agence Nationale de la Recherche, HORIZON EUROPE Framework Programme