Get started
Work

Pax proteins mediate segment-specific functions in proximal tubule survival and response to ischemic injury

Year: 2024
Type: article
Abstract: Acute kidney injury (AKI) is a common clinical syndrome with few effective treatments. In this report, we identify a novel and proximal tubule segment-specific role for the Pax family of transcription factors in the differential sensitivity of proximal tubule segments to ischemic AKI. These results may lead to new therapeutic targets for the prevention and treatment of AKI.
DOI: 10.1152/ajprenal.00289.2024
Authors: Madison C. McElliott, Asha C. Telang, Jenna T. Ference-Salo, Anas Al-Suraimi, Mahboob Chowdhury, Edgar A. Otto, Abdul Soofi, Gregory R. Dressler, Jeffrey A. Beamish
Language: English
Subfield: Nephrology
Field: Medicine
Open Access status: hybrid
Awards: G2581463391, G2809023810, University of Michigan O'Brien Kidney Translational Core Center, G4959644004, G6232678685, G6372374577
OpenAlex ID: W4405028701
FWCI: 1.477
Cites: 54
Cited by: 6
Related to: 10