Renshen (Radix Ginseng) polysaccharide promotes repair of the mice intestinal mucosa through regulatory mechanisms based on polyamine and human antigen R.
Year: 2024
Type: article
Abstract: OBJECTIVE: ) polysaccharide on colonic injury induced by dextran sulfate sodium (DSS) in mice. METHODS: Mice were fed 3% (w/v) DSS for 6 d to create colonic lesions. A cell-migration model was created using cell scratching. mRNA expression, protein expression, translation efficiency of mRNA, and nucleoplasmic distribution of human antigen R (HuR) were determined by real-time reverse transcription-quantitative polymerase chain reaction, western blotting, a dual luciferase reporter system, and immunofluorescence staining, respectively. RESULTS: ) polysaccharide promoted the migration of IEC-6 cells and affected expression of stromal interaction molecule 1 (STIM1) and cell division cycle 42 (Cdc42) at transcriptional and post-transcriptional levels. CONCLUSIONS: ) on the intestinal mucosa.
Source: PubMed
Authors: Wang Guanyu, Dai Xingzhen, Liu Yiting, Zhu Zeming, H U Ling, L I Ruliu
Institution: Guangzhou University of Chinese Medicine
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4405028868