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Prevalence, Incidence, and Age at Diagnosis of Boys With Hypospadias: A Nationwide Population-Based Epidemiological Study

Year: 2025

Type: article

Abstract: PURPOSE: The aim of this study was to assess the diagnostic prevalence, incidence, diagnostic age, and surgical volume of hypospadias in Denmark. MATERIALS AND METHODS: Males with a hypospadias diagnosis in the Danish National Patient Registry (n = 10,276) were identified (1977-2019). A diagnostic algorithm, validated by medical file review (n = 1710), confirmed diagnoses and severity (distal/proximal). The yearly prevalence (live-born hypospadias boys/100,000 newborn boys) and incidence (first hypospadias registration in the Danish National Patient Registry/100,000 boys in background population) were calculated. Age at diagnosis and number of health care contacts were calculated. Poisson regression was used to analyze temporal trends. RESULTS: ) nonsurgical hospital contacts (median = 5, IQR, 3-7 vs median = 2, IQR, 1-3). At least 1 surgical admission was recorded for 4550 (58.4%). Boys without surgical admissions (n = 3244, 41.6%) were primarily distal cases (97.7%). CONCLUSIONS: Since 1977, the prevalence of diagnosed hypospadias cases significantly increased and peaked around 800 per 100,000 live boys in 2007. The diagnostic age decreased, proximal cases were diagnosed earlier, and there were more surgical admissions than distal cases. A significant proportion were never operated.

Source: The Journal of Urology

DOI: 10.1097/ju.0000000000004319

Authors: Tina L. Leunbach, Agnethe Berglund, Andreas Ernst, Gitte M. Hvistendahl, Yazan F. Rawashdeh, Claus H. Gravholt

Institutions: Aarhus University, Aarhus University Hospital

Language: English

Topic: Urological Disorders and Treatments

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,000