Year: 2024
Type: article
Abstract: ABSTRACT A new azaphilone, botryazaphilone (1), the first example of azaphilone featuring a 6/6/5/5 tetracyclic system, together with two known ones, chermesinone A (2) and perangustol B (3), had been obtained from the marine sponge‐associated fungus Botryosporium pulchrum. The structure of 1 was elucidated through the analysis of spectroscopic data, whereas its absolute configuration was determined via single‐crystal x‐ray diffraction. It is the first report of the secondary metabolites isolated from the genus Botryosporium. Furthermore, all the compounds showed potential anti‐inflammatory activities on the model of CuSO4‐induced transgenic zebrafish.
Source: Chemistry & Biodiversity
Authors: Dai‐Chun Li, Mei‐Wen Wei, Zhen‐Yu Yang, Ze‐Jie Guo, Xiao‐Jian Liao, Shi‐Hai Xu, Bing‐Xin Zhao
Institution: Jinan University
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G2687361912, G4252368123
OpenAlex ID: W4405036587