Work

Efficient encapsulation of insulin by a giant macrocycle as a powerful approach to the inhibition of its fibrillation

Year: 2024

Type: article

Abstract: . Such complexation behavior is distinctive to traditional macrocycles, which can only recognize amino acid residues from the side due to their limited cavity sizes. Control experiments also proved that smaller cucurbit[7]uril and carboxylatopillar[5]arene could not prevent insulin from fibrillation under the same test conditions. Notably, co-administration with equimolar PP[3]AS maintained normoglycemia for at least 300 min in streptozotocin-induced diabetic model mice, whereas mice that received free insulin became hyperglycemic again within ∼150 min.

Source: Chemical Science

DOI: 10.1039/d4sc06859a