Work

The addition of peri-operative gentamicin with ciprofloxacin reduces infection and sepsis rates post transrectal prostate biopsy

Year: 2024

Type: article

Abstract: Objective: Despite the advent of transperineal (TP) biopsy and reduced risk of infective complications, transrectal ultrasound-guided (TRUS) prostate biopsy is still widely performed worldwide. The accepted prophylactic antibiotic is usually a single agent oral fluoroquinolone; however, this approach is beset by growing antibiotic resistance. The aim of this study was to assess whether the addition of intravenous gentamicin (2 mg/kg or at least 160 mg), immediately prior to biopsy, in conjunction with routine ciprofloxacin prophylaxis, reduced infection and sepsis rates post TRUS biopsy. Method: test was utilized for continuous variables for statistical significance. Results: value = 0.005). We found no associated between infection and secondary risk factors. Conclusion: The administration of 2 mg/kg intravenous gentamicin with oral ciprofloxacin prophylaxis reduces infection and sepsis rates post TRUS biopsy.

Source: Prostate International

DOI: 10.1016/j.prnil.2024.11.006

Authors: Arjun Guduguntla, Andrew Xu, Kieran W. Benn, Prassannah Satasivam

Institutions: Northern Health, The University of Melbourne

Language: English

Topic: Surgical site infection prevention

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,800